The film starts and Peter Parker is a socially awkward teen
in high school that has a crush on Gwen Stacy and is bullied by Flash Thompson.
He lives with his Aunt (May) and Uncle (Ben) after his parents disappearance
many years before.
After a day at school, he comes back home and finds his dads
research that reveals he worked at Oscorp with fellow scientist Doctor Curt
Connors. Peter manages to sneak into a lab at Oscorp where ‘biocable’ is under
development from genetically modified spiders. After sneaking inside Peter is
bitten by one of the spiders. On the subway ride home, Peter discovers he has
spider-like abilities.
After studying his father’s papers and research he goes to
visit Doctor Connors and gives to him the missing piece in Doctor Connors
experiments. Doctor Connors then invites Peter to work with him on the
experiments on regenerating limbs. After working on the experiments with Doctor
Connors at his lab he forgets to pick up his aunt. When he gets home he has an
argument with his uncle and storms out.
At a nearby deli, Peter is two cents short and can’t afford
milk. As Peter is about to leave, a thief comes into the store and steals the
money from the teal which Peter keenly observes. While searching for Peter, Ben
tries to stop the thief but is shot in the process. Peter then finds Ben
bleeding and dying from the gun shot.
After Uncle Ben’s death, Peter starts using his new
abilities to track down criminals matching the killer’s description. After
falling through the rough of an old abandoned gym, Peter notices a luchador
poster which inspires Peter to don a mask and spandex costume to hide his
identity.
Peter is then invited to a dinner from Gwen and meets her
father Captain George Stacy and have a conversation about Spider-Man (Peter’s
alter-ego). After the dinner Peter reveals to Gwen that he is Spider-Man and
they share a kiss.
After successful trials on regenerating limbs on a mouse,
Connors tests the experiment on himself after pressure from his superior Doctor
Ratha. Doctor Connors then goes to stop Doctor Ratha using the experiments on
hospital patients but on his way his skin starts to turn green and scaly and
starts to become the ‘Lizard’. Peter Parker as Spider-Man intercepts him at the
bridge and snatches all of the falling cars with his web lines.
Peter then unsuccessfully confronts the Lizard who he
suspects is Doctor Connors. During the confrontation Doctor Connors/Lizard
finds out Spider-Man’s identity and goes to his high school where they fight
before Lizard escapes. Following this the police start a manhunt on both
Spider-Man and Lizard.
The police then corner Spider-Man where Captain Stacy finds
out that Peter is Spider-Man. Lizard plans to make all humans a lizard like
creature by releasing a chemical cloud from Oscorp Tower. Spider-Man eventually
releases an antidote through the cloud and saves the city but not before Lizard
mortally wounds Captain Stacy. Before his death, Captain Stacy makes Peter vow
to keep Gwen safe which Peter initially does but later suggests to Gwen at
school he may see her after all.